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KMID : 0379520010170010027
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한국독성학회지
2001 Volume.17 No. 1 p.27 ~ p.32
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Embryo and Fetal Developmental Toxicity Study on Gamma-Irradiated Korean Ginseng in Rats
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Park Kui-Lea
Shin Jae-Hoo
Kim Pan-Gyi
Jang Seung-Jae
Lee Yu-Mi
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Abstract
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Korean ginseng products have been fumigated with ethylene oxide (EO) for sterilization and prolongation of storage periods. However, there had been controversies indicating that consumption of EO treated foods might cause harmful effects in human. In Korea, the use EO gas for food treatment was banned in 1991. Since then, irradiation technique has been developed as an alternative. This study was carried out to evaluate the safety of irradiated ginseng on embryo and fetal developmental toxicity effects in rats. Either EO gas fumigated or gamma-irradiated ginseng was administered to pregnant Wistar rats by oral gavage from gestational day 7 to 17. The amount of irradiation used in this study was 5, 10 and 30 kGy, respectively. There were no treatment related changes of dams in deaths, clinical signs, food consumption and body/organ weight. No treatment related changes in implantation ratio, litter size, sex ratio and body/organ weight of fetuses were observed. Also, no F1fetuses with external, visceral, head and skeletal mal-formation were observed. The results of this study showed that gamma-irradiated ginseng, up to 30 kGy, has no adverse effects on fetal development of rats.
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KEYWORD
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Teratogenic effect, Korean ginseng, {gamma}-irradiation, Rat
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